SCHEIB, H., MCLAY, I., GUEX, N., CLARE, J.J., BLANEY, F.E., DALE, T.J., TATE, S.N. & ROBERTSON, G.M. (2006). Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anaesthetic binding. J Mol Model 12 (6), 813-22

BURBIDGE, S.A., DALE, T.J., POWELL, A.J., WHITAKER, W.R., XIE, X.M., ROMANOS, M.A. & CLARE, J.J. (2002). Molecular cloning, distribution and functional analysis of the NA(V)1.6. Voltage-gated sodium channel from human brain. Brain Res Mol Brain Res 103(1-2), 80-90.

XIE, X., DALE, T.J., JOHN, V.H., CATER, H.L., PEAKMAN, T.C. & CLARE, J.J. (2001). Electrophysiological and pharmacological properties of the human brain type IIA Na+ channel expressed in a stable mammalian cell line. Pflugers Arch 441 (4), 425-33

CHEN, Y.H., DALE, T.J., ROMANOS, M.A., WHITAKER, W.R., XIE, X.M. & CLARE, J.J. (2000). Cloning, distribution and functional analysis of the type III sodium channel from human brain. Eur J Neurosci 12(12), 4281-9

DUPERE, J.R., DALE, T.J., STARKEY, S.J. & XIE, X. (1999). The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels. Br J Pharmacol 128 (5), 1011-20

CLARE, J.J., DALE, T.J., XIE, X., PEAKMAN, T.C. & CHEN, Y. (1999). Cloning and functional analysis of the type III Na+ channel from human brain. Ann N Y Acad Sci 868, 80-3

Vince Groppi

Click to View Selected Publications from Vince Groppi

COFFINO, P. AND GROPPI, V.E. Growth regulation of S49 lymphoma cells: analysis of cAMP responsiveness and polyamine metabolism. In Advances in Cyclic Nucleotide Research, Vol. 14, pp.399-410. P. Greengard and G.A. Robinson (eds). Raven Press, New York (1981)

GROPPI, V.E., STEINBERG, F., KASLOW, H.R., WALKER, N. AND BOURNE, H.R. Identification by direct photoaffinity labeling of an altered phosphodiesterase in mutant S49 cells. J. Biol. Chem. 258:9717-9723 (1983)

GADWOOD, R.C., KAMDAR, B.V., CIPKUS DUBRAY, L.A., WOLFE, M.L., SMITH, M.P., WATT, MIZSAK, S.A. AND V.E. GROPPI. Synthesis and Biological Activity of Spirocyclic Benzopyran Imidazolone Potassium Channel Openers. J. Med. Chem. 36:1480-1487 (1993)

SPANSWICK D., SMITH MA, GROPPI V.E., LOGAN S.D., ASHFORD M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390:521-525 (1997)

HAJOS M, HURST RS, HOFFMANN WE, KRAUSE M, WALL TM, HIGDON NR, GROPPI VE. The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. Pharmacol Exp Ther. 312:1213-1222 (2005)

U.S. Patents

5,882,873. Human DNA sequence encoding a kidney ATP-dependent potassium channel. M.J. Bienkowski and V.E. Groppi

6,693,172 Double mutant alpha-7 nicotinic acetylcholine receptor. V.E. Groppi, M.L. Wolfe and M. Berkenpas

Dyke McEwen

Click to View Selected Publications from Dyke McEwen

MCEWEN DP, MARTENS JR. Antifibrillatory agents and potassium channels in the atria: pore block versus channel trafficking. Mol Interv. 2009 Apr;9(2):79-86. Review.

MCEWEN DP, LI Q, JACKSON S, JENKINS PM, MARTENS JR. Caveolin regulates kv1.5 trafficking to cholesterol-rich membrane microdomains. Mol Pharmacol. 2008 Mar;73(3):678-85.

MCEWEN DP, SCHUMACHER SM, LI Q, BENSON MD, IÑIGUEZ-LLUHÍ JA, VAN GENDEREN KM, MARTENS JR. Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytes. J Biol Chem. 2007 Oct 5;282(40):29612-20.

MCEWEN DP, ISOM LL. Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules. J Biol Chem. 2004 Dec 10;279(50):52744-52. Epub 2004 Oct 4.

MCEWEN DP, MEADOWS LS, CHEN C, THYAGARAJAN V, ISOM LL. Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. J Biol Chem. 2004 Apr 16;279(16):16044-9.

KAZARINOVA-NOYES K, MALHOTRA JD, MCEWEN DP, MATTEI LN, BERGLUND EO, RANSCHT B, LEVINSON SR, SCHACHNER M, SHRAGER P, ISOM LL, XIAO ZC. Contactin associates with Na+ channels and increases their functional expression. J Neurosci. 2001 Oct 1;21(19):7517-25.

Dave Rock

Click to View Selected Publications from Dave Rock

SCHELKUN, RM, YUEN, P, MALONE, TC, ROCK, DM, STOEHR, SJ, SZOKE, B AND TARCZY-HORNOCH, K. Synthesis and biological activity of substituted Bis-(4-hydroxyphenyl) methanes as N-type calcium channel blockers. Bioorg Med Chem Lett 9 (16): 2447-52, 1999.

ROCK, DM, HORNE, WA, STOEHR, SJ, HASHIMOTO, C, ZHOU, M, CONG, R, AND PALMA, A. Does a1E code for T-type Ca2+ channels? A comparison of recombinant E Class Ca2+ channels with GH3 pituitary T-type and recombinant B Class Ca2+ channels. In Low-Voltage-Activated T-type Calcium Channels (Nargeot, J, Clozel, P and Tsien, RW, Eds.). Adis Press, 279-289, 1998.

STOEHR, SJ, CAMPBELL, GW, AND ROCK, DM. Evaluation of N-type Ca2+ channel currents in cultured rat superior cervical ganglion neurons. Drug Dev Res 41: 85-90, 1997.

ROCK, DM AND MACDONALD, RL. Polyamine regulation of N-methyl-D-aspartate receptor channels. Annual Rev Pharmacol Toxicol 35:463-82, 1995.

ROCK, DM, KELLY, KM AND MACDONALD, RL. Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons. Epilepsy Res 16:89-98, 1993.

ROCK, DM AND MACDONALD, RL. Spermine and related polyamines produce a voltage-dependent reduction of N-methyl-D-aspartate receptor single channel conductance. Mol Pharmacol 42:157-64, 1992.

ROCK, DM, MCLEAN MJ, MACDONALD RL, CATTERALL WA AND TAYLOR CP. Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spiral cord neurons and displace batrachotoxin A 20-a-benzoate binding in vitro. Epilepsy Res 8:197-203, 1991.

Del Trezise

Click to View Selected Publications from Del Trezise

HOUGAARD, C., JENSEN, M.L., DALE, T.J., MILLER, D, DAVIES, D.J., ERIKSEN, B.L., STROBAEK, D., TREZISE, D.J., CHRISTOPHERSON, P. (2009). Selective Activation of the SK1 Subtype of Human Small Conductance Ca2+-Activated K+ Channels by GW542573X is Dependent on Serine 293 in the Pore Region. Mol Pharm. 76, 569-580.

HOLLANDS, E.C., DALE, T.J., BAXTER, A.W., SEWAGUDDE, D., MEADOWS, H.J., POWELL, A.J. CLARE, J.J & TREZISE, D.J. (2009). Population patch clamp electrophysiology analysis of recombinant GABA-A a1b3y2 channels expressed in HEK-293T cells. J Biomol. Screen. 14, 769-780.

DALE, T.J., TOWNSEND, C., HOLLANDS, E.C. & TREZISE, D.J. (2007). Population patch clamp: a breakthrough technology for ion channel screening. Mol. Biosyst. 3, 714-722.

JOHN, V.H., DALE, T.J., HOLLANDS, E.H., CHEN, M.X., PARTINGTON, L., DOWNIE, D.L., MEADOWS, H.J. & TREZISE, D.J. (2007). Novel 384-well population patch clamp electrophysiology assays for Ca2+-activated K+ channels. J. Biomol. Screening, 12. 50-60.

BAHIA, P.K., SUZUKI, R., BENTON, D.C., JOWETT, A.J., CHEN, M.X., TREZISE, D.J., DICKENSON AH, MOSS GW. (2005) A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes. J Neurosci. 25(14):3489-98.

TATE, S., BENN, S., HICK, C., TREZISE, D.J., JOHN, V., MANNION, R.J., COSTIGAN, M., PLUMPTON, C., GROSE, D., GLADWELL, Z., KENDALL, G., DALE, K., BOUNTRA, C. & WOOLF, C.J. (1998). Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons. Nature Neuroscience., 1, 653-656.

TREZISE, D.J., JOHN, V.H. & XIE, X.M. (1998). Voltage- and use-dependent inhibition of Na+ channels in rat sensory neurones by 4030W92, a new antihyperalgesic agent. Br. J. Pharmacol., 124, 953-963.