Ion Channel Discovery

DRUG DISCOVERY SOLUTIONS

Ion channels are complex, multi-subunit proteins that govern the movement of ions across the cell membrane - they present unique opportunities and challenges for drug discovery. As inventors of two paradigm shifting ion channel assay technologies, IonWorks and FLIPR, we have a deep understanding of the biological and technical requirements for constructing relevant ion channel assays. Melded with our Service Division’s extensive experience and drug discovery track record in voltage-gated, ligand-gated and other types of ion channels, we also have the bigger picture. Together, we provide a unique problem solving ion channel resource.

REAGENTS & ASSAYS

Generation of recombinant cell lines, validation of native cells, off-the -shelf and de novo planar array electrophysiology and ion-sensitive fluorophore assays and screens. Cell lines for sale including hNaV1.7 - please enquire.

SCREENING, PROFILING & MECHANISTIC PHARMACOLOGY

Electrophysiology and fluorescence assays for hit identification (screens up to 50K), hit validation, SAR and lead optimization. Small molecules, biologics and siRNA. Detailed mechanistic profiling a specialty.

Read more about Essen mechanistic screening

AUTOMATED & MANUAL PATCH CLAMP

Essen-customized IonWorks Quattro technology - 1000s of electrophysiology data points per day, with rigorous QC. Full voltage-protocols & mechanistic screening. Manual patch clamp systems and highly trained electrophysiologists.

Read more IonWorks automated patch-clamp

OPTICAL ASSAYS

FLEXstation assays for Ca²⁺, K⁺ (Tl⁺) and Na⁺ (V_m) permeable channels.